Supercritical Carbon Dioxide Extraction of Glycyrrhizin from Licorice Root
نویسندگان
چکیده
As the development of the natural medicine, the glycyrrhizin extracted from the licorice root was found to have potential therapeutic value in the treatment of several diseases, especially available for anti-SARS virus . Therefore, the purpose of this work was to find an optimal method to extract and refine the glycyrrhizin. In this work, the extraction of glycyrrhizin by means of organic solvents and supercritical carbon dioxide (SC-CO2) was investigated. The SC-CO2 extraction apparatus was designed and set up by our own laboratory. The experimental conditions was as follows: pressure 10MPa-30MPa, temperature from 30 ? to 60 ? , CO2 flow rate about 10kg/h. The constitution of the solvent, and the particle size were all discussed in order to obtain the maximum extraction yield. The extraction of glycyrrhizin from licorice root with supercritical carbon dioxide was also compared with conventional extraction methods. Those methods include the extraction at room temperature (ERT), the traditional Soxhlet extraction, and the heat reflux extraction. The results show that the yield obtained by SC-CO2 extraction was similar to that obtained by conventional solvent extraction. But the quality of the production extracted by SC-CO2 was better than that of the production extracted by other methods. Subsequently, HPLC was used to analyze the chemical compositions of these productions.
منابع مشابه
novel process for extraction of natural sweetener from licorice Glycyrrhiza glabra) roots
Pressurized hot water extraction (PHWE) is a very useful technique for recovering bioactive molecules from natural materials using subcritical compressed liquid water in the temperature range of 50–150 ◦C. A novel process has been developed for making a natural sweetener from licorice (Glycyrrhiza glabra) roots involving selective chemical reaction and easy separation, for recovering mono-ammon...
متن کاملSupercritical Carbon Dioxide Extraction of Bioactive Compounds from Feijoa (Feijoa sellowiana) Leaves
Background and Objectives: Supercritical fluid extraction (SFE) technique has been studied for extraction of bioactive compounds from Feijoa sellowiana leaves. Results were compared with those obtained from conventional ethanolic extraction (CE). Materials and Methods: Results: The best supercritical carbon dioxide (SC-CO2) extraction conditions was determined as 250 bar of pressure, 50 °...
متن کاملRisk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.
Licorice (or 'liquorice') is a plant of ancient origin and steeped in history. Licorice extracts and its principle component, glycyrrhizin, have extensive use in foods, tobacco and in both traditional and herbal medicine. As a result, there is a high level of use of licorice and glycyrrhizin in the US with an estimated consumption of 0.027-3.6 mg glycyrrhizin/kg/day. Both products have been app...
متن کاملThe Percent of Extract and Glycyrrhizin Content of Glycyrrhia glabra Root Grown in Kerman Province and Some Samples from Fars Province by HPLC Method
Background & Aims: Licorice (Glycyrrhia glabra L.) is an important herbal medicine that its root extract has long been used for the treatment of various diseases. The essential component of its root is glycyrrhizin. This study was performed to determine the percentage of the extract and glycyrrhizin content of the roots of Glycyrrhiz glabra grown in different areas of Kerman province and some s...
متن کامل